Amphetamine induces dopamine efflux through a dopamine transporter channel
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چکیده
منابع مشابه
Amphetamine induces dopamine efflux through a dopamine transporter channel.
Drugs of abuse, including cocaine, amphetamine (AMPH), and heroin, elevate extracellular dopamine (DA) levels in the brain, thereby altering the activity/plasticity of reward circuits and precipitating addiction. The physiological release of DA occurs through the calcium-dependent fusion of a synaptic vesicle with the plasma membrane. Extracellular DA is cleared by uptake through the Na+/Cl- -d...
متن کاملSimple transporter trafficking model for amphetamine-induced dopamine efflux.
Amphetamine and its derivatives are important drugs of abuse causing both short-term excitatory and long-term addictive effects. The short-term excitatory effects are linked to amphetamine's ability to maintain high levels of dopamine (DA) outside the cell both by inhibiting DA reuptake after synaptic transmission and by enhancing the efflux of DA from the dopaminergic cells. The molecular mech...
متن کاملMOL #48447 1 Syntaxin1A Interaction with the Dopamine Transporter Promotes Amphetamine- Induced Dopamine Efflux
Department of Molecular Physiology & Biophysics, Center for Molecular Neuroscience, Kennedy Center for Research on Human Development, Vanderbilt University, 7124 MRBIII, 465 21 Ave S., Nashville, TN 37232 (FB, CD, EB, SED, BJL, RJC, KE, AG); Departments of Psychiatry and Pharmacology, Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, P&S 11-401, 630 W 16...
متن کاملIntracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.
Although it is clear that amphetamine-induced dopamine (DA) release mediated by the dopamine transporter (DAT) is integral to the behavioral actions of this psychostimulant, the mechanism of this release is not clear. In this study, we explored the requirement for intracellular Ca(2+) in amphetamine-induced DA efflux and currents mediated by the human DAT. The patch-clamp technique in the whole...
متن کاملSyntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein syntaxin 1A (SYN1A) interacts with and regulates the function of transmembrane proteins, including ion channels and neurotransmitter transporters. Here, we define the first 33 amino acids of the N terminus of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A. Amphetamine (AMPH) incre...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0407737102